The consumption of Solalum Lycopersicum has increased in recent years and with it its production and the waste generated as a result of cultivation and processing. For this reason, the present work aims to evaluate and determine whether there are significant differences between the different methods of recovery of tomato by-products. The bibliographic review through which 52 articles published almost completely in the last five years were selected: twelve for the extraction of carotenoids, ten for the extraction of phenolic compounds, four for pectin and seven for the formation of biogas. The food valorization of tomato is wide and little studied yet. The extraction of phenolic compounds, pectin or lycopene offers a wide range of new possibilities. Emerging pretreatment methods such as high pressures, electrical pulses or supercritical CO2 open the possibility of improving the extraction of bioactive compounds and achieving a circular economy. It is concluded that further studies are needed to confirm and investigate the effectiveness and cost-effectiveness of emerging methods, which are generally the most efficient for the extraction of target compounds.

The attempt to bring closer biological treatments, with high cost for citizens, has boosted the birth and growth of biosimilar drugs. Molecules whose production is focused on being copies of the active ingredients of drugs of biological origin catalogued as innovative. As they are biological molecules, the fact of being copies of the active ingredient becomes complex, as small variations in their biochemical composition can affect their safety and efficacy. Unlike innovators, whose marketing rationale is aimed at the safety of the drug through clinical studies, the basis for being marketed under safe conditions, however, biosimilar drugs focus on ensuring that their quality attributes are as close as possible to the molecule they are intended to replace. For this reason, by studying the critical quality attributes and the modulators that affect them, it is possible to establish a classification of these attributes that will allow harmonization of the biosimilar concept. The attributes that characterize the molecules are antagonistic or complementary to each other, making it possible to establish a range of acceptance that allows the development of a system for grading the comparability between innovators and biosimilars, bringing the concept, which to date has been theoretical, closer to a quantitative aspect. But always taking into consideration fundamental aspects such as the incidence of laboratory error in its assessment. Therefore, based on a harmonized model of the concept of the quality attribute, this should be reformulated towards a term that unifies the concept with its intrinsic error, so that it can be assessed in a harmonized way.